Cytogenetics

Course Outline: (34 hours)

Contents:

1. Introduction, background and definitions

2. Comparative study of chromosome structure in creatures, especially human

3. Cell cycle and important genes responsible for its regulation

4. Various chromosome culture and staining methods (blood, bone marrow and types of tissue)

5. Preparation of karyotype and its cytogenetic applications

6. Structural abnormalities of chromosomes, mechanisms of appearance and importance diseases of human

7. Numerical chromosome abnormalities, mechanisms of appearance and importance diseases of human

8. Relationship between chromosome abnormalities and gene-related diseases (lack of gonadal development, hermaphroditism)

9. Environmental factors and chromosomes

10. Chromosomal fracture syndromes with recessive inheritance (fanconi, bloom) exchange of sibling pieces

11. Hybridization and gene map

12. Prenatal cytogenetic diagnosis methods

13. Miscarriage, infertility, sexual ambiguity, and genetic counseling in chromosomal aberrations